The season 10 premiere of Grey's Anatomy is right around the corner, so it would be a good time for me to lay out my predictions for the premiere and beyond...
Spoilers will be mentioned, so read on at your own risk...
Dr. Richard Webber: In the season 9 finale, we last saw Richard lying in the basement of the hospital after being electrocuted. I kept going back and forth on whether he was going to survive or die, but after watching the promo for the season 10 premiere, I think it's a safe bet to say that Richard will survive, but an intern (Mousey) will meet her demise. Catherine Avery (Jackson's mom) will be back this season, so we'll see their relationship grow and I can see Catherine possibly moving to Seattle to be with Richard or (and it's a very big or) Richard leaving the hospital to be with Catherine.
Crowen (Cristina and Owen): With the news of Sandra Oh (Cristina Yang) leaving the show after season 10, it's obvious that Crowen will officially be over near the end of the upcoming season. Until the break up (which I believe will be Cristina initiating the break up with Owen), they will remain a couple. Eventually Owen will find someone new and he'll get the family he's always wanted.
MerDer (Meredith and Derek): With the birth of a son in the season 9 finale, season 10 will find the couple spending more time at home and less time at work and with this being Grey's Anatomy, nothing goes smoothly as the couple will face some "tension due to family vs. career." Despite this upcoming tension, I'm going to say that they, as a couple, are safe unless Patrick Dempsey or Ellen Pompeo decide to leave after season 10.
Calzona (Callie and Arizona): In the season 9 finale, Arizona cheated on her wife with Dr. Lauren Boswell and Callie found out which led to a confrontation in which Arizona made it clear that she still holds resentment towards her wife for making the decision to have her leg amputated. In a sneak peek from the season 10 premiere, Callie tells the other board members, Owen and Bailey that Arizona slept with Boswell. From the season premiere press release, Callie makes a "bold decision" regarding her marriage and in a press release for episode 3, Arizona tries to fix her broken marriage while Callie continues to shut her out. Clearly Arizona knows what she did was wrong and wants to make things right, but she needs to get help for herself first in regards to her PTSD and resentment towards Callie before she can fix her marriage. As for Callie, it's understandable that she's hurt, so it's no surprise that she's willing to listen to Arizona so soon after the cheating. Will they work things out? This is a tough one to call because it really can go either way. I would like to see the first few episodes before I guess at what's going to happen, but I'm going to go ahead and say that they will work things out, but it's going to take some time. If the show ends after this season, then they'll get back together at the end. If the show continues, they could drag the separation storyline out even longer.
Will Grey's Anatomy continue beyond season 10?: Another tough question. There is no denying that the show still brings in good ratings and the entertainment president of ABC has said that the network would like to see that show remain on the air for many years to come, but that isn't a guarantee that will happen because the show is losing Oh and Dempsey and/or Pompeo could follow suit. If that happens, can the show continue without those three? That's a tough question to answer, but it can happen which is why I'm going to say that the show will have a season 11 if Dempsey and Pompeo return. If they don't, I can see the show ending this season.
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